The exploration of the crystal form landscape is described in detail, including polymorph screens, concomitant polymorphs, and disappearing polymorphs. A survey of analytical methods for studying and characterizing polymorphs is followed by a discussion of rapidly developing computational methods for studying and attempting to predict polymorphic behavior. A chapter with many examples of the utilization of polymorphic systems to investigate structure—property relationships in solids precedes three individual chapters on the role and importance of polymorphism in pharmaceuticals, high energy materials, and pigments.
The book closes with a chapter on the role of polymorphism in establishing and protecting intellectual property connected with polymorphs through the patent system. Keywords: polymorphism , solid form landscape , thermodynamic factors , kinetic factors , disappearing polymorphs , structure—property relations , pharmaceuticals , explosives , pigments , patents.
Forgot password? Don't have an account? All Rights Reserved. In the last two decades, there has been a sharp rise in the interest in olymorphic systems, as an intrinsically interesting phenomenon, and as an increasingly important component in the development and marketing of a variety of materials based on organic molecule e. This book summarizes and brings up to date the current knowledge and understanding of polymorphism of molecular crystals, and concentrates it in one comprehensive source.
The book will be invaluable reference for students, researchers, and professionals in the field. Preface Chapter 1. Introduction and historical background Chapter 2. Fundamentals Chapter 3. Analytical methods for characterizing polymorphs Chapter 5. Conformational polymorphism- intra- and intermolecular energetics Chapter 6. Polymorphism and structure- property relations Chapter 7. Not registered? Sign up. Publications Pages Publications Pages.
Recently viewed 0 Save Search. Users without a subscription are not able to see the full content. Polymorphism in Molecular Crystals Joel Bernstein Abstract Polymorphism — the multiplicity of structures or forms — is a term used in many disciplines.
More Polymorphism — the multiplicity of structures or forms — is a term used in many disciplines. Authors Affiliations are at time of print publication. Porter III, S.
Elie, A. Matzger, Polymorphism in carbamazepine cocrystals. Bag, C. Reddy, Screening and selective preparation of polymorphs by fast evaporation method: a case study of aspirin, anthranilic acid, and niflumic acid.
Bag, M. Patni, C. Reddy, A kinetically controlled crystallization process for identifying new co-crystal forms: fast evaporation of solvent from solutions to dryness. Alhalaweh, S. Velaga, Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying. Tan, Conformational polymorphs of a muscle relaxant, metaxalone. Thirunahari, S. Aitipamula, A. Wong, P. Tan, Polymorphism and phase transformations of a cocrystal of nicotinamide and pimelic acid.
Thakuria, M. Eddleston, E. Chow, G. Lloyd, B. Aldous, J. Krzyzaniak, A. Bond, W. Jones, Use of in situ atomic force microscopy to follow phase changes at crystal surfaces in real time. Nangia, Conformational polymorphism in organic crystals. Parveen, R. Davey, G. Dent, R. Pritchard, Linking solution chemistry to crystal nucleation: the case of tetrolic acid. Tan, Polymorphs and solvates of a cocrystal involving an analgesic drug, ethenzamide, and 3,5-dinitrobenzoic acid.
Tan, Novel solid forms of the anti-tuberculosis drug, isoniazid: ternary and polymorphic cocrystals. Childs, K. Hardcastle, Cocrystals of piroxicam with carboxylic acids. Bernstein, R. Davey, J. Henck, Concomitant polymorphs. Dunitz, J. Bernstein, Disappearing polymorphs. Goud, A. Du, Y. Zhou, Y. Gong, C. Zhao, Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs. Asian J. MacGillivray, Engineering cocrystal and polymorph architecture via pseudoseeding.
Jones, Pharmaceutical cocrystallization: engineering a remedy for caffeine hydration. Srinivasulu Aitipamula 1 Email author 1. Personalised recommendations. Cite chapter How to cite?
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